Figure 2.

Disruption of adult olfactory neurogenesis. (A) Gamma irradiation was targeted to the SVZ, protecting the rest of the brain with a lead shield (for details see Lazarini et al., 2009; Feierstein et al., 2010). The SGZ, the site of hippocampal neurogenesis, was not affected. (B) Adult neurogenesis was reduced in the OB of irradiated (IRR) compared to control (CTRL) females. Density of adult-born neurons is measured as the density of DCX⁺ (a marker expressed in immature neurons) cells in the OB 6.5 months after irradiation. ^*p < 0.01. OB, olfactory bulb; SVZ, subventricular zone; RMS, rostral migratory stream; SGZ, subgranular zone. Modified from Feierstein et al. (2010).