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. 2012 Oct 2;33(12):2601–2610. doi: 10.1093/carcin/bgs300

Fig. 1.

Fig. 1.

Antioxidants reverse E2-mediated decrease in SOD3 mRNA and protein expression. (A) SOD3 mRNA expression in E2-exposed mammary tumors and in mammary tissues of rats treated with E2, BHA or Vit C for 240 days. (B) SOD3, SOD2 and SOD1 protein expression in E2-exposed mammary tumors and in mammary tissues of rats treated with E2, BHA or Vit C for 240 days. The bar graph represents fold change in SOD3, SOD2 and SOD1 protein expression (mean ± SEM) in mammary tumors and in mammary tissues from at least three different animals compared with age-matched control mammary tissues. (C) Protein expression of SOD3, SOD2 and SOD1 in MCF-10A cells treated with E2 (10nM), BHA (250 µM) or Vit C (1mM) for 24h. The bar graph represents fold change in SOD3, SOD2 and SOD1 protein expression (mean ± SEM) in MCF-10A cells from at least three different replicates from three individual experiments compared with vehicle-treated MCF-10A cells. The symbols ‘E2#’ or ‘+#’ indicate E2-induced mammary tumor tissues and the symbol ‘*’ indicates P value <0.05 compared with respective controls.