. 2012 Oct 2;33(12):2417–2423. doi: 10.1093/carcin/bgs308

Table III.

Association of GWAS-identified colorectal cancer risk variants and adenomas by subgroups in European Americans, the Tennessee Colorectal Polyp Study, 2003–11

SNP	Allele^a	Non-advanced versus advanced					Single versus multiple
		Non-advanced adenomas		Advanced adenomas		P _{heterogeneity}	Single adenoma		Multiple adenomas		P _{heterogeneity}
		OR (95% CI)^b	P value	OR (95% CI)^b	P value	P _{heterogeneity}	OR (95% CI)^b	P value	OR (95% CI)^b	P value	P _{heterogeneity}
rs6691170	T/G	1.06 (0.96–1.17)	0.288	1.06 (0.91–1.24)	0.440	0.941	1.07 (0.96–1.19)	0.221	0.95 (0.81–1.10)	0.470	0.194
rs6687758	G/A	1.06 (0.94–1.20)	0.357	1.06 (0.87–1.28)	0.556	0.996	1.09 (0.96–1.25)	0.189	0.90 (0.74–1.09)	0.273	0.100
rs10936599	T/C	0.98 (0.88–1.10)	0.736	0.93 (0.78–1.11)	0.407	0.602	1.06 (0.94–1.19)	0.375	0.88 (0.74–1.04)	0.138	0.085
rs7758229	T/G	1.04 (0.94–1.16)	0.399	1.10 (0.94–1.28)	0.244	0.609	1.08 (0.97–1.21)	0.157	1.01 (0.86–1.17)	0.936	0.446
rs16892766	C/A	1.00 (0.84–1.21)	0.963	1.19 (0.92–1.55)	0.195	0.299	1.09 (0.90–1.32)	0.386	1.00 (0.76–1.31)	0.978	0.600
rs10505477	A/G	1.07 (0.97–1.18)	0.194	1.34 (1.15–1.55)	1.7×10 ⁻⁴	0.014	1.05 (0.94–1.16)	0.411	1.28 (1.11–1.48)	0.001	0.028
rs10808555	G/A	1.03 (0.93–1.14)	0.570	1.10 (0.94–1.28)	0.251	0.513	1.02 (0.91–1.14)	0.744	1.07 (0.92–1.25)	0.371	0.600
rs6983267	G/T	1.07 (0.97–1.18)	0.181	1.32 (1.13–1.53)	4.3×10 ⁻⁴	0.025	1.05 (0.95–1.17)	0.336	1.26 (1.09–1.46)	0.002	0.051
rs7837328	A/G	1.06 (0.96–1.17)	0.269	1.29 (1.11–1.50)	0.001	0.030	1.07 (0.96–1.19)	0.203	1.22 (1.05–1.41)	0.007	0.163
rs7014346	A/G	1.05 (0.95–1.16)	0.382	1.22 (1.05–1.43)	0.010	0.093	1.04 (0.94–1.17)	0.442	1.20 (1.03–1.39)	0.017	0.146
rs10795668	A/G	0.92 (0.82–1.02)	0.119	0.92 (0.78–1.09)	0.325	0.988	0.90 (0.80–1.02)	0.095	0.98 (0.83–1.14)	0.760	0.457
rs3802842	C/A	1.04 (0.94–1.16)	0.437	1.15 (0.98–1.35)	0.092	0.325	1.03 (0.91–1.15)	0.670	1.14 (0.98–1.33)	0.100	0.288
rs7136702	T/C	1.05 (0.95–1.16)	0.318	1.03 (0.88–1.21)	0.685	0.841	1.05 (0.94–1.17)	0.361	1.07 (0.92–1.24)	0.392	0.876
rs4444235	C/T	1.03 (0.94–1.14)	0.517	1.08 (0.93–1.25)	0.342	0.654	1.01 (0.91–1.12)	0.828	1.05 (0.91–1.21)	0.525	0.698
rs4779584	T/C	1.15 (1.02–1.30)	0.020	1.22 (1.02–1.47)	0.029	0.592	1.08 (0.95–1.24)	0.248	1.26 (1.06–1.50)	0.009	0.169
rs9929218	A/G	0.94 (0.84–1.04)	0.246	0.79 (0.67–0.94)	0.009	0.107	0.91 (0.80–1.02)	0.097	0.93 (0.79–1.09)	0.360	0.811
rs4939827	C/T	0.86 (0.78–0.95)	0.003	0.95 (0.82–1.11)	0.545	0.272	0.91 (0.81–1.01)	0.074	0.88 (0.76–1.02)	0.089	0.754
rs10411210	T/C	0.91 (0.78–1.07)	0.247	0.98 (0.77–1.25)	0.882	0.610	1.03 (0.88–1.22)	0.695	0.82 (0.64–1.05)	0.121	0.131
rs961253	A/C	0.99 (0.89–1.11)	0.916	1.02 (0.86–1.20)	0.857	0.834	0.98 (0.87–1.11)	0.770	1.03 (0.88–1.21)	0.693	0.623
rs4925386	T/C	0.80 (0.72–0.90)	1.1×10 ⁻⁴	0.77 (0.65–0.92)	0.004	0.703	0.80 (0.71–0.90)	3.0×10 ⁻⁴	0.75 (0.63–0.89)	0.001	0.516

^aMinor/major allele as reported from GWAS of colorectal cancer. All results based on the minor allele (bold) of the SNP evaluated.

^bAdjusted for age, sex, body mass index, cigarette smoking and alcohol drinking.