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. 2012 Oct 2;33(12):2417–2423. doi: 10.1093/carcin/bgs308

Table III.

Association of GWAS-identified colorectal cancer risk variants and adenomas by subgroups in European Americans, the Tennessee Colorectal Polyp Study, 2003–11

SNP Allelea Non-advanced versus advanced Single versus multiple
Non-advanced adenomas Advanced adenomas P heterogeneity Single adenoma Multiple adenomas P heterogeneity
OR (95% CI)b P value OR (95% CI)b P value OR (95% CI)b P value OR (95% CI)b P value
rs6691170 T/G 1.06 (0.96–1.17) 0.288 1.06 (0.91–1.24) 0.440 0.941 1.07 (0.96–1.19) 0.221 0.95 (0.81–1.10) 0.470 0.194
rs6687758 G/A 1.06 (0.94–1.20) 0.357 1.06 (0.87–1.28) 0.556 0.996 1.09 (0.96–1.25) 0.189 0.90 (0.74–1.09) 0.273 0.100
rs10936599 T/C 0.98 (0.88–1.10) 0.736 0.93 (0.78–1.11) 0.407 0.602 1.06 (0.94–1.19) 0.375 0.88 (0.74–1.04) 0.138 0.085
rs7758229 T/G 1.04 (0.94–1.16) 0.399 1.10 (0.94–1.28) 0.244 0.609 1.08 (0.97–1.21) 0.157 1.01 (0.86–1.17) 0.936 0.446
rs16892766 C/A 1.00 (0.84–1.21) 0.963 1.19 (0.92–1.55) 0.195 0.299 1.09 (0.90–1.32) 0.386 1.00 (0.76–1.31) 0.978 0.600
rs10505477 A/G 1.07 (0.97–1.18) 0.194 1.34 (1.15–1.55) 1.7×10 −4 0.014 1.05 (0.94–1.16) 0.411 1.28 (1.11–1.48) 0.001 0.028
rs10808555 G/A 1.03 (0.93–1.14) 0.570 1.10 (0.94–1.28) 0.251 0.513 1.02 (0.91–1.14) 0.744 1.07 (0.92–1.25) 0.371 0.600
rs6983267 G/T 1.07 (0.97–1.18) 0.181 1.32 (1.13–1.53) 4.3×10 −4 0.025 1.05 (0.95–1.17) 0.336 1.26 (1.09–1.46) 0.002 0.051
rs7837328 A/G 1.06 (0.96–1.17) 0.269 1.29 (1.11–1.50) 0.001 0.030 1.07 (0.96–1.19) 0.203 1.22 (1.05–1.41) 0.007 0.163
rs7014346 A/G 1.05 (0.95–1.16) 0.382 1.22 (1.05–1.43) 0.010 0.093 1.04 (0.94–1.17) 0.442 1.20 (1.03–1.39) 0.017 0.146
rs10795668 A/G 0.92 (0.82–1.02) 0.119 0.92 (0.78–1.09) 0.325 0.988 0.90 (0.80–1.02) 0.095 0.98 (0.83–1.14) 0.760 0.457
rs3802842 C/A 1.04 (0.94–1.16) 0.437 1.15 (0.98–1.35) 0.092 0.325 1.03 (0.91–1.15) 0.670 1.14 (0.98–1.33) 0.100 0.288
rs7136702 T/C 1.05 (0.95–1.16) 0.318 1.03 (0.88–1.21) 0.685 0.841 1.05 (0.94–1.17) 0.361 1.07 (0.92–1.24) 0.392 0.876
rs4444235 C/T 1.03 (0.94–1.14) 0.517 1.08 (0.93–1.25) 0.342 0.654 1.01 (0.91–1.12) 0.828 1.05 (0.91–1.21) 0.525 0.698
rs4779584 T/C 1.15 (1.02–1.30) 0.020 1.22 (1.02–1.47) 0.029 0.592 1.08 (0.95–1.24) 0.248 1.26 (1.06–1.50) 0.009 0.169
rs9929218 A/G 0.94 (0.84–1.04) 0.246 0.79 (0.67–0.94) 0.009 0.107 0.91 (0.80–1.02) 0.097 0.93 (0.79–1.09) 0.360 0.811
rs4939827 C/T 0.86 (0.78–0.95) 0.003 0.95 (0.82–1.11) 0.545 0.272 0.91 (0.81–1.01) 0.074 0.88 (0.76–1.02) 0.089 0.754
rs10411210 T/C 0.91 (0.78–1.07) 0.247 0.98 (0.77–1.25) 0.882 0.610 1.03 (0.88–1.22) 0.695 0.82 (0.64–1.05) 0.121 0.131
rs961253 A/C 0.99 (0.89–1.11) 0.916 1.02 (0.86–1.20) 0.857 0.834 0.98 (0.87–1.11) 0.770 1.03 (0.88–1.21) 0.693 0.623
rs4925386 T/C 0.80 (0.72–0.90) 1.1×10 −4 0.77 (0.65–0.92) 0.004 0.703 0.80 (0.71–0.90) 3.0×10 −4 0.75 (0.63–0.89) 0.001 0.516

aMinor/major allele as reported from GWAS of colorectal cancer. All results based on the minor allele (bold) of the SNP evaluated.

bAdjusted for age, sex, body mass index, cigarette smoking and alcohol drinking.