Table IV.
Cumulative association of the weighted genotype risk score on variable phenotypes of colorectal polyps in European Americans, the Tennessee Colorectal Polyp Study, 2003–11
| Type of colorectal polyps | No. of cases | OR (95% CI), by quintile of weighted genetype risk scorea | Per-allele associationa | P heterogeneity | |||||
|---|---|---|---|---|---|---|---|---|---|
| Q1 (low) | Q2 | Q3 | Q4 | Q5 | OR (95% CI) | P trend | |||
| Overall | 2127 | Reference | 1.19 (0.98–1.43) | 1.21 (1.00–1.46) | 1.41 (1.17–1.69) | 1.75 (1.46–2.10) | 1.14 (1.10–1.19) | 1.5×10−10 | 0.341 |
| Any adenomas | 1564 | Reference | 1.28 (1.04–1.58) | 1.20 (0.97–1.48) | 1.47 (1.20–1.80) | 1.86 (1.52–2.27) | 1.15 (1.10–1.20) | 7.3×10−10 | |
| Hyperplastic polyps only | 563 | Reference | 0.96 (0.70–1.31) | 1.23 (0.91–1.65) | 1.22 (0.91–1.64) | 1.47 (1.10–1.96) | 1.11 (1.04–1.18) | 0.002 | |
| Adenomas | |||||||||
| Non-advanced adenomas | 1152 | Reference | 1.33 (1.06–1.67) | 1.15 (0.91–1.45) | 1.47 (1.18–1.84) | 1.73 (1.39–2.16) | 1.13 (1.07–1.18) | 1.6×10−6 | 0.038 |
| Advanced adenomas | 394 | Reference | 1.17 (0.79–1.71) | 1.45 (1.00–2.11) | 1.48 (1.02–2.13) | 2.29 (1.62–3.23) | 1.22 (1.13–1.32) | 6.7×10−7 | |
| Single adenoma | 908 | Reference | 1.28 (1.00–1.64) | 1.11 (0.86–1.42) | 1.41 (1.11–1.80) | 1.58 (1.24–2.00) | 1.11 (1.05–1.17) | 1.7×10−4 | 0.039 |
| Multiple adenomas | 435 | Reference | 1.24 (0.86–1.78) | 1.29 (0.90–1.84) | 1.57 (1.11–2.21) | 2.05 (1.46–2.86) | 1.19 (1.10–1.28) | 7.5×10−6 | |
| Single small adenoma | 715 | Reference | 1.30 (1.00–1.71) | 1.06 (0.80–1.41) | 1.45 (1.12–1.89) | 1.54 (1.19–2.01) | 1.10 (1.04–1.17) | 9.3×10−4 | 0.005 |
| Advanced and multiple adenomas | 150 | Reference | 1.07 (0.57–2.02) | 1.52 (0.84–2.73) | 1.36 (0.75–2.47) | 2.73 (1.60–4.67) | 1.28 (1.13–1.45) | 7.0×10−5 | |
| Distal adenomas | 522 | Reference | 1.31 (0.96–1.78) | 1.03 (0.74–1.42) | 1.29 (0.95–1.75) | 1.54 (1.14–2.08) | 1.09 (1.02–1.17) | 0.012 | 0.038 |
| Any proximal adenomas | 882 | Reference | 1.24 (0.95–1.61) | 1.27 (0.98–1.65) | 1.49 (1.15–1.92) | 2.08 (1.63–2.66) | 1.19 (1.12–1.25) | 1.3×10−9 | |
| Distal adenomas | 522 | Reference | 1.31 (0.96–1.78) | 1.03 (0.74–1.42) | 1.29 (0.95–1.75) | 1.54 (1.14–2.08) | 1.09 (1.02–1.17) | 0.012 | 0.001 |
| Advanced proximal adenomas | 229 | Reference | 1.05 (0.61–1.80) | 1.82 (1.12–2.96) | 1.55 (0.94–2.53) | 2.93 (1.86–4.61) | 1.31 (1.18–1.45) | 2.2×10−7 | |
| Age <50 years | 101 | Reference | 1.14 (0.56–2.35) | 1.13 (0.55–2.34) | 1.10 (0.53–2.28) | 2.69 (1.44–5.03) | 1.27 (1.10–1.47) | 0.001 | 0.031 |
| Age 50–65 years | 1132 | Reference | 1.28 (1.01–1.62) | 1.20 (0.95–1.53) | 1.58 (1.26–1.99) | 1.87 (1.50–2.35) | 1.16 (1.10–1.22) | 6.2×10−9 | |
| Age >65 years | 331 | Reference | 1.42 (0.97–2.08) | 1.23 (0.84–1.82) | 1.31 (0.90–1.92) | 1.58 (1.09–2.28) | 1.08 (1.00–1.18) | 0.050 | |
aSixteen SNPs were used to construct the score, including rs6691170, rs6687758, rs10936599, rs7758229, rs16892766, rs10505477, rs10795668, rs3802842, rs7136702, rs4444235, rs4779584, rs9929218, rs4939827, rs10411210, rs961253 and rs4925386. Results were adjusted for age (except for the analysis stratified by age), sex, body mass index, cigarette smoking and alcohol drinking.