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Real-time qPCR analysis showing the effects of 4b on the expression of the indicated ubiquitination-related genes in the striatum of N171-82Q transgenic mice. Values shown are the mean ± SEM expression values (n = 5–6 mice per group) compared with a wt expression level of 1, which is indicated by the dotted line. Significant differences were determined by Student's t-tests (unpaired; one-tailed) at the indicated treatment time points. *P < 0.05; **P < 0.01; +P < 0.08.
