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. 2012 Oct 5;287(49):40850–40857. doi: 10.1074/jbc.R112.389056

FIGURE 3.

FIGURE 3.

Superposition of active-site residues from the substrate complexes of B. halodurans RNase H1 (magenta) and human RNase H1 (orange) and the complex of HIV-1 RNase H containing the natural product hydroxytropolone β-thujaplicinol (blue) (89). Metal ions (Mg2+ for B. halodurans RNase H1, Ca2+ for human RNase H1, and Mn2+ for HIV-1 RNase H) are depicted as spheres. The RNA strand from the B. halodurans RNase H1-substrate complex is shown in pink. The inhibitor from the HIV-1 RNase H co-crystal structure has been omitted for clarity.