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A potential phospholipid binding site for the hAPPL2BARPH PH domain. The hAPPL2BARPH chain A monomer was superimposed with the ARHGAP9 PH domain bound to inositol (1,4,5)-trisphosphate (PDB code 2P0D). Shown is the ARHGAP9 bound conformation of the Ins(1,4,5)P3 and the electrostatic surface of hAPPL2BARPH chain A. The inset highlights the contact residues for ARHGAP9 PH domain (green) and the superimposed residues of hAPPL2BARPH (magenta) showing the correspondence between the two.
