FIGURE 6.
Pair-wise alignment of full-length hAPPL1 and hAPPL2. Equivalent residues are highlighted in gray. The four helices of the BAR domain are indicated by orange underline, the PH domain by green underline, and the linker region by purple underline. The four basic residues that form the basic patch at the apex of the convex surface in APPL2BARPH are boxed and shown in blue (see Fig. 2 APPL2 (AB) convex surface). It is evident from this alignment that the PH domain is more highly conserved than the BAR domain and that helix 4 is the least conserved of the four BAR domain helices.