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msh2-msh6 L1129C/S1137C causes an elevated mutation rate. A, patches of msh3Δ msh6Δ strains expressing plasmid-borne msh6 alleles (Table 1) were replica plated onto plates lacking leucine and threonine to test for MMR complementation by suppression of hom3–10 reversion. B, residues equivalent to S. cerevisiae Msh6 Leu1129 and Ser1137 are depicted by spheres on the ribbon diagram of human Msh2-Msh6 with the C terminus of Msh6 in black.
