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Residues L1129C and S1137C form a disulfide bond in oxidized Msh2-Msh6 L1129C/S1137C. A, schematic of the alkylation reactions. B, ratio of carbamidomethylation in the oxidized sample to carbamidomethylation in the reduced sample for Msh6 L1129C/S1137C cysteines. The error bars indicate the S.D. C, residues equivalent to the cysteines in S. cerevisiae Msh6 are depicted by black spheres on the ribbon diagram human Msh2-Msh6.
