Table 2.

C–N-bond-formation cross coupling of N-protected 4-bromo-7-azaindoles 1 with amides 2.

Entry	7-Azaindole 1	Amide 2	Product 3a	Time (h)	Yield (%)b
1	1a	2a	–	24	NRc
2	1b	2a	–	5	0d
3	1c	2a	3a	2	95
4	1c	2b	3b	3	85
5	1c	2c	3c	2.5	92
6	1d	2d	3d	3	91
7	1d	2e	3e	3	89
8	1d	2f	3f	3	85
9	1e	2a	3g	2	95

^aReactions of N-protected 7-azaindoles 1 (1.0 mmol) with amides 2 (1.2 mmol) were performed in a sealed Schlenk tube at 100 °C in dioxane (2 mL) by using Pd(OAc)₂ (5 mol %), Xantphos (10 mol %) and base (1.5 mmol). ^bYields reported are isolated yields. ^cNR no reaction. ^dDesulfonation reaction takes place.