Table 1.
Cytotoxicity of the fluorinated cryptophycins 22 and 31 in comparison to cryptophycin-52 (2).
| IC50 [pM] (KB-3-1) | IC50 [nM] (KB-V1) | FR | |
| 2 | 15.5 | 0.26 | 16.7 |
| 22 | 66.0 | 10.1 | 153 |
| 31 | 2970 | 98.4 | 33 |
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