Table 9.5.4.

T Cell Specificity Studies using Positional Scanning Libraries

Organism	Tcc	Research Area	Antigen	Method a	Reference
CD4
Human	CSF-3	Infectious diseases	Unknown	Biometrical	Hemmer et al., 1999
Human	TL3A6	Autoimmunity	MBP 87-99	Traditional Biometrical	Hemmer et al., 2000 Zhao et al, 2001a
Human	MN b	Autoimmunity	Unknown	Biometrical	Sospedra et al, 2005
Human	GP5F11	Infectious diseases	Flu HA 306-318	Biometrical and Traditional	Markovic-Plese et al, 2005
Human	Clone 6	Infectious diseases	Gag 272-281	Biometrical	Venturini et al, 2006
Human	X8	Infectious diseases	Unknown	Biometrical	Luneman et al, 2007
Human	VRC b	Infectious diseases	Unknown	Biometrical	Judkowski et al, 2011
Mouse	Tg (BAND)	Model system	PCC	Traditional	Wilson et al., 1999
Mouse	Tg (BDC2.5)	Autoimmunity	Unknown	Traditional Biometrical	Judkowski et al, 2001 Judkowski et al, 2004
CD8
Human	LAU 203/1.5	Cancer	Melan-A 26-35	Traditional Biometrical	Pinilla et al., 2001 Rubio-Godoy et al, 2002b
Human	3-3F4	Infectious diseases	pp65 495-503	Traditional	La Rosa et al, 2001
Human	LAU 50/4D7	Cancer	Unkown	Biometrical and Traditional	Rubio-Godoy et al, 2002a
Human	LAU Tyr/34	Cancer	Tyrosinase 368-376	Biometrical and Traditional	Rubio-Godoy et al, 2002c
Human	N1216	Infectious diseases	Tax 11-19	Biometrical	Nino-Vasquez et al, 2004
Human	161jAX14	Infectious diseases	Gag 77-85	Biometrical and Traditional	Boggiano et al, 2005
Mouse	Tg 3K-36	Model system	Unkown	Traditional	Huseby et al, 2005
Mouse	p773-782	Cancer	Her-2 neu 773-782	Traditional	Lustgarten et al, 2006

^aMethod used for the identification of peptides. Traditional refers to peptides derived from the combination of amino acids based on activity of positional scanning library. Biometrical refers to the identification of peptides in protein databases derived from the positional scanning based biometrical analysis.

^bMultiple clones.