Fig. 5.

When testing with a single enclosure shape, firing patterns of the CA3 network remained highly consistent for repetitions of the same environment over extended time intervals, whereas activity patterns in the CA1 network changed. (A) An experimental design with a single enclosure shape was used to test whether the decorrelation of hippocampal activity patterns could have been an effect of intervening experiences in a different context (Fig. 3). The mean PV correlation between pairs of recordings in the same enclosure shape (B) and the corresponding cumulative distribution function for the PVs (C) are shown as described in Fig. 3. Highly consistent firing patterns in the CA3 population were observed over time intervals of 30 min to 30 h. In contrast, the CA1 network continued to show a pronounced monotonic decrease in firing similarity with time (see text for statistics).