Fig. 4.

MYCN binds preferentially to up-regulated genes. (A) ChIP-on-chip analysis of MYCN and control in IMR32. The percentage of significant (FDR < 0.05) bound promoters at the TSS (TSS-1) and ± 2,000 bp (TSS-2000) is shown. (B) The percentage of genes with a CACGTG ± 100 bp (TSS-100) or ± 2,000 bp (TSS-2000) is shown. The analysis was performed for MYCN-157 (regulated: yes), the up-and down-regulated subsets, and all other genes (regulated: no). *Significant association (P < 0.01) between bound/unbound genes or presence/absence of CACGTG and regulation in the MYCN-157 sets (two-sided Fisher’s exact test).