Table 1.
Gene ontology classes enriched in MYCN-157
| GO description | Total no. genes in set | No. genes regulated | P value | Gene symbols* |
| Cell cycle | 807 | 20 | 1.50E-05 | OIP5, E2F5, SKA3, NCAPH, POLA2, PHGDH, LIG3, MCM3, MCM5, POLD2, POLE2, TIPIN, HJURP, PKIA, RAD51, RRM2, ANAPC1, E2F8, RAD54L, KIF23 |
| DNA replication | 144 | 7 | 1.20E-05 | POLA2, LIG3, MCM3, MCM5, POLD2, POLE2, RRM2 |
| Mitotic cell cycle | 299 | 10 | 8.00E-05 | E2F5, NCAPH, POLA2, MCM3, MCM5, POLD2, POLE2, RRM2, ANAPC1, KIF23 |
| S phase of mitotic cell cycle | 105 | 5 | 4.90E-04 | POLA2, MCM3, MCM5, POLD2, POLE2 |
| G1/S transition of mitotic cell cycle | 129 | 5 | 3.30E-03 | POLA2, MCM3, MCM5, POLE2, RRM2 |
| DNA repair | 250 | 7 | 7.80E-03 | RAD51AP1, MSH6, LIG3, POLD2, POLE2, RAD51, RAD54L |
| Small GTPase-mediated signal transduction | 277 | 7 | 0.02 | RUNDC3A, ARL4D, RHOC, ARHGEF3, RAB6B, RND2, DIRAS3 |
*Underlined symbols are down-regulated by MYCN; the others are up-regulated by MYCN.