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. 2012 Nov 5;109(47):19426–19431. doi: 10.1073/pnas.1217477109

Fig. 5.

Fig. 5.

RNF167 knockdown affects AMPAR but not NMDAR currents in hippocampal neurons. Scatter plots show amplitude of EPSCs for single pairs (○) and the mean (●). Representative superimposed traces are shown [black, control (CTL); green, shRNF167 or shRNF167 + RNF167*]. (Scale bars: A and B, 20 pA and 20 ms; C and D, 20 pA and 50 ms.) Bar graphs show that expression of shRNF167 affects AMPAR currents (A; 105% increase, n = 8, *P = 0.04) but not NMDAR currents (C; 22.5% increase, n = 9, P = 0.91). The expression of shRNF167 and RNF167 resistant (RNF167*) rescued AMPAR currents to level similar to control (B; 29.1% increase, n = 9, P = 0.43) without affecting NMDAR currents (D; 12.2% increase, n = 9, P = 0.69). Errors bars represent mean ± SEM. See also Fig. S1D for rescue construct expression.