Table 1.
Dosing cohorts
| Cohort | n | Conversion Strategy | Weekly Epoetin Alfa Dose | Peginesatide Starting Dose | Epoetin Alfa–to-Peginesatide Dose Conversion Ratio (U/kg/wk:mg/kg/mo) | 1-Week ESA-Free Interval |
|---|---|---|---|---|---|---|
| A |
15 |
Dose conversion ratio |
NA |
NA |
3030:1 |
No |
| B |
15 |
Dose conversion ratio |
NA |
NA |
2439:1 |
No |
| C |
14 |
Dose conversion ratio |
NA |
NA |
2000:1 |
No |
| D |
30 |
Dose conversion ratio |
NA |
NA |
2000:1 |
Yes |
| E |
15 |
Dose conversion ratio |
NA |
NA |
1515:1 |
Yes |
| F |
15 |
Tiered weight-based |
<100 U/kg |
0.050 mg/kg |
<2000:1 |
Yes |
| |
|
|
100 to 150 U/kg |
0.075 mg/kg |
1333 to 2000:1 |
|
| |
|
|
> 150 to 200 U/kg |
0.100 mg/kg |
1500 to 2000:1 |
|
| |
|
|
>200 U/kg |
0.150 mg/kg |
>1333:1 |
|
| G |
30 |
Tiered weight-based |
<100 U/kg |
0.050 mg/kg |
<2000:1 |
No |
| |
|
|
100 to 150 U/kg |
0.075 mg/kg |
1333 to 2000:1 |
|
| |
|
|
>150 to 200 U/kg |
0.100 mg/kg |
1500 to 2000:1 |
|
| |
|
|
>200 U/kg |
0.150 mg/kg |
>1333:1 |
|
| |
|
|
|
|
|
|
| H |
30 |
Tiered fixed-dose |
<8000 U |
4.0 mg |
<2000:1 |
No |
| |
|
|
8000 to 16000 U |
6.0 mg |
1333 to 2666:1 |
|
| |
|
|
>24000 U |
12.0 mg |
1333 to 2000:1 |
|
| 16.0 mg | >1500:1 |
Abbreviation: ESA, erythropoiesis-stimulating agent.