Figure 3.
Expression pattern of Muc4 during the progression of pancreatic cancer in KrasG12Dmouse model. (A) Muc4 mRNA expression was determined by quantitative real time PCR. (B, C, D, E, F, and G) Muc4 protein expression during the progression of pancreatic cancer in KrasG12D mouse model (H) Composite scores of pancreatic tissues of KrasG12D;Pdx1-Cre mice stained with Muc4 antibody. (I) Normal pancreas from 50 week old mice were negative for Muc4 expression. (J, K, L) Muc4 expression in the metastatic lesions involving liver, small intestines and lungs, respectively in 50 weeks old KrasG12D mice.