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. 2012 Oct 26;5:68. doi: 10.1186/1756-8722-5-68

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Copyright ©2012 Rachagani et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Inflammation during the progression of pancreatic cancer in Kras^G12Dmouse model. (A) Percentage of inflammation in the pancreas of 7 to 50 weeks old Kras^G12D;Pdx1-Cre mice evaluated on H&E stained tissue sections. (B) Expression of mRNA of the inflammatory cytokines/chemokines IFNγ, CXCL1 and CXCL2 in the pancreas of 50 weeks old Kras^G12D;Pdx1-Cre mice compared to LSLKras^G12D (i.e. normal, unfloxed) animals. (C) Infiltration of lymphocytes into the pancreas of Kras^G12D;Pdx1-Cre mice. Lymphocytes (L) that infiltrated into the pancreas of Kras^G12D;Pdx1-Cre mice are shown within the blue boundaries in the H&E stained tissues. Light microscopic pictures are magnified 200x for each age group. D) Composite scores of pancreatic tissues of Kras^G12D;Pdx1-Cre mice stained with F4/80 antibody for macrophages. (E, F, G, H) F4/80 marker expression for macrophages during the progression of pancreatic cancer in Kras^G12D;Pdx1-Cre mouse model was analyzed by IHC.