Table 4.
Antimicrobial agents used in patients with HAP and VAP
|
Empiric antibiotic |
|
HAP (n = 218) |
|
|
VAP (n = 130) |
|
|---|---|---|---|---|---|---|
| Adequate (n = 128) | Inadequate (n = 90) | p | Adequate (n = 44) | Inadequate (n = 86) | p | |
| Carbapenems |
31 (24.2) |
16 (17.8) |
0.004 |
20 (45.5) |
18 (20.9) |
<0.001 |
| Third generation cefalosporine |
31 (24.2) |
27 (30.0) |
|
4 (9.1) |
20 (23.3) |
|
| β-lactam + β- lactamase inhibitor |
35 (27.3) |
21 (23.3) |
|
14 (31.8) |
26 (30.2) |
|
| Quinolone |
21 (16.4) |
16 (17.8) |
|
0 |
10 (11.6) |
|
| β-lactam in combination with quinolone |
1 (0.8) |
9 (10.0) |
|
0 |
9 (10.5) |
|
| Aminoglycoside in combination with carbapenem or β-lactam | 9 (7.0) | 1 (1.1) | 6 (13.6) | 3 (3.5) |