Table 1.
Base-case annual probabilities associated with LAM-resistant CHB
|
Initial state |
Entered state |
HBeAg (+) |
|
HBeAg (−) |
|
Source |
|---|---|---|---|---|---|---|
| Estimate (%) | Range (%) | Estimate (%) | Range (%) | |||
| Lamivudine-resistant CHB |
Compensated cirrhosis |
2.7 |
1.6-3.8 |
6.2 |
2.8-9.7 |
[27] |
| |
Hepatocellular carcinoma |
0.4 |
0.3-0.6 |
0.4 |
0.3-0.6 |
[27] |
| Virological response |
Compensated cirrhosis |
0.5 |
0.3-0.8 |
1.2 |
0.7-2 |
[25] |
| |
Hepatocellular carcinoma |
0.2 |
0.1-0.4 |
0.2 |
0.1-0.4 |
[25] |
| Multi-resistant CHB |
Compensated cirrhosis |
2.7 |
1.6-3.8 |
6.2 |
2.8-9.7 |
[27] |
| |
Hepatocellular carcinoma |
0.4 |
0.3-0.6 |
0.4 |
0.3-0.6 |
[27] |
| Compensated cirrhosis |
Decompensated cirrhosis |
7.3 |
3.5-10 |
7.3 |
3.5-10 |
[28] |
| |
Hepatocellular carcinoma |
3.4 |
1-10 |
3.4 |
1-10 |
[28] |
| |
Death |
4.9 |
2-14 |
4.9 |
2-14 |
[28] |
| Decompensated cirrhosis |
Hepatocellular carcinoma |
3.4 |
1-10 |
3.4 |
1-10 |
[28] |
| |
Liver transplantation |
5 |
1-10 |
5 |
1-10 |
[5] |
| |
Death |
14.4 |
10-20 |
14.4 |
10-20 |
[5] |
| Hepatocellular carcinoma |
Liver transplantation |
5 |
1-10 |
5 |
1-10 |
[5] |
| |
Death |
23.3 |
20-30 |
23.3 |
20-30 |
[5] |
| Liver transplantation | Death | 7 | 2-12 | 7 | 2-12 | [5] |
CHB, chronic hepatitis B.