Table 5. Sex-dependent multivariate Cox-PH Model for the Risk of Stroke in Subjects With and Without Depression (GDS ≥5)/Antidepressant Medication, Adjusted for Known Risk Factors*.
Women | Men | |||||||
Events/N | HR | 95% CI | P-value (Wald) | Events/N | HR | 95% CI | P-value (Wald) | |
GDS ≥5 | 84/2202 | 1.34 | 0.80 to 2.26 | 0.273 | 71/1524 | 1.00 | 0.52 to 1.91 | 0.996 |
Antidepressant | 84/2202 | 0.95 | 0.48 to 1.88 | 0.881 | 71/1524 | 0.73 | 0.22 to 2.44 | 0.614 |
GDS ≥5 or antidepressant | 84/2202 | 1.62 | 1.02 to 2.57 | 0.043 | 71/1524 | 0.85 | 0.44 to 1.62 | 0.618 |
Adjusted for age, sex, BMI, smoking, hypertension, diabetes, hyperlipidemia, previous myocardial infarction, previous TIA, previous stroke, history of atrial fibrillation, and physical activity.
HR, hazard ratio.