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. 2012 Nov 30;7(11):e50803. doi: 10.1371/journal.pone.0050803

Table 5. Sex-dependent multivariate Cox-PH Model for the Risk of Stroke in Subjects With and Without Depression (GDS ≥5)/Antidepressant Medication, Adjusted for Known Risk Factors*.

Women Men
Events/N HR 95% CI P-value (Wald) Events/N HR 95% CI P-value (Wald)
GDS ≥5 84/2202 1.34 0.80 to 2.26 0.273 71/1524 1.00 0.52 to 1.91 0.996
Antidepressant 84/2202 0.95 0.48 to 1.88 0.881 71/1524 0.73 0.22 to 2.44 0.614
GDS ≥5 or antidepressant 84/2202 1.62 1.02 to 2.57 0.043 71/1524 0.85 0.44 to 1.62 0.618
*

Adjusted for age, sex, BMI, smoking, hypertension, diabetes, hyperlipidemia, previous myocardial infarction, previous TIA, previous stroke, history of atrial fibrillation, and physical activity.

HR, hazard ratio.