Figure 3. Pharmacophores used for the identification of (a) PPARγ full agonists and (B) PPARγ partial agonists.

Hydrophobic and acceptor/donor sites are colored in green and pink, respectively. Excluded volumes are showed as yellow spheres. The ligands farglitazar (from the PDB entry 1FM9) and nTZDpa (from the PDB entry 2Q5S) are also represented.