Table 1. Lung Histopathology Cotton Rats.

Total Score for Each Histological Parameter
Treatment	Bronchiolitis	Vasculitis	Bronchitis	Alveolitis	Pneumonitis	Mean, all measures
PBS alone	0	0	1	0	0	0.13
PBS+Chal	5	0	10	5	1	2.63
RSV+Chal	1	1	2	2	0	0.75
FI-RSV+Chal	15	0	19	9	2	5.63
1 ug RSV-F	6	0	9	2	0	2.13
1 ug RSV-F+ alum	7	5	7	5	0	3.43
6 ug RSV-F	5	0	11	3	0	2.71
6 ug RSV-F+ alum	0	0	7	2	0	1.13
30 ug RSV-F	6	2	13	6	1	3.50
30 ug RSV-F+ alum	1	0	6	3	0	1.43

Lung histopathology scores from cotton rats immunized with the indicated dose of RSV F (RSV-F) nanoparticles without or with aluminum phosphate adjuvant (RSV-F+alum), live RSV then challenged (RSV+Chal), PBS then challenged (PBS+Chal), or PBS alone. Cotton rats (n = 7 or 8 per group) were immunized on day 0 and day 21 and challenged with RSV virus on day 49. Lung tissues were harvested on day 54 and subjected to histopathology and blinded samples scored for severity on a scale of 0 to 4. Total and mean of all measures per animal for bronchiolitis, perivasculitis, bronchitis, alveolitis and pneumonitis are given.