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. 2012 Nov 30;7(11):e50860. doi: 10.1371/journal.pone.0050860

Table 1. Inhibition data for CA II, IX, XII and XIV for the parent CA inhibitor AZ, HS680 and the control agent as determined by stopped-flow CO2 hydration method.

Ki (nM) Ki Ratios
Compound hCA II hCA IX hCA XII hCA XIV hCA II/IX hCA XII/IX hCA XIV/IX
AZ 12 25 5.7 41 0.5 0.2 1.6
HS680 248 7.5 35 66 33.1 4.7 8.8
Control >1000 >1000 >1000 >1000