Table 1. Inhibition data for CA II, IX, XII and XIV for the parent CA inhibitor AZ, HS680 and the control agent as determined by stopped-flow CO2 hydration method.
Ki (nM) | Ki Ratios | ||||||
Compound | hCA II | hCA IX | hCA XII | hCA XIV | hCA II/IX | hCA XII/IX | hCA XIV/IX |
AZ | 12 | 25 | 5.7 | 41 | 0.5 | 0.2 | 1.6 |
HS680 | 248 | 7.5 | 35 | 66 | 33.1 | 4.7 | 8.8 |
Control | >1000 | >1000 | >1000 | >1000 | – | – | – |