Figure 4. Peb1A-mediated amino acid uptake in C. jejuni 81-176 is important for its persistence in the murine intestine and liver.

Mice were orally (A) or intraperitoneally (B) co-infected with the C. jejuni 81-176 wild-type strain (black diamonds) and the peb1A mutant (white diamonds). The bacterial load in the intestine and liver of the infected animals was examined 5 weeks after infection. The pairs of black and white diamonds indicate the CFU numbers of C. jejuni 81-176 and its peb1A mutant that could be recovered from the indicated organs of one animal. The combined results of two independent infection experiments are shown. The Mann–Whitney U test was used to calculate the P values for the statistical differences between the CFU numbers of the different strains: P<0.001 (A) and P<0.05 (B).