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. 2012 Nov 30;7(11):e50699. doi: 10.1371/journal.pone.0050699

Figure 6. Tissue-specific impact of proline catabolism on C. jejuni 81-176 mouse colonization.

Figure 6

Shown is the colonization efficiency of C. jejuni 81-176 wild-type (black diamonds) and its isogenic putP mutant strain (white diamonds) in a murine model of infection. The colonization of the intestine (A) and liver (B) was evaluated 5 weeks after oral (A) or intraperitoneal (B) co-infection of myd88 −/−, nramp −/− mice, respectively. Each pair of black and white diamonds represents the CFU numbers of C. jejuni 81-176 wild-type strain and its putP mutant recovered from the indicated organs of an individual animal. The combined results of four (A) and three (B) independent infection experiments are shown. The Mann–Whitney U test was used to calculate the P values for the statistical differences between the CFU numbers of the different strains: P<0.001 (A) and P ≥ 0.05 (B).