Figure 4. Slit-lamp image of LEGSKO and age matched wild type mouse lens.

(A). Representative images of HOM-LEGSKO mouse lens at 4 and 9 months compared with age matched control wild type mouse lens. The same mouse was followed over a period of 9 months and lens images were taken every two months. (B). Slit-lamp images were taken periodically and lens opacity/cataract of any size were recorded for 9 months in homozygous LEGSKO mice vs. age matched wild type mice (n = 30 mice per group). LEGSKO mice developed lens opacities and cataract at much higher rate compared to wild type mice.