Table 1. Sexual behavior and expected HIV-1 transmissions in one year, stratified by CD4 count and plasma viral load.
Expected transmissions in 1 year in a population of 100,000** | |||||||
Sex acts per month | Condom use *** | ||||||
CD4 cells/µL | Plasma viral load, copies/mL | n (%) | mean (SD) | % protected | Reported | Half | None |
350–499 | <10,000 | 455 (18.3) | 5.9 (6.6) | 77.6 | 292 (8.9) | 466 (9.0) | 637 (9.2) |
10,000–49,999 | 318 (12.8) | 6.6 (8.9) | 75.5 | 571 (17.3) | 887 (17.1) | 1,180 (17.0) | |
≥50,000 | 266 (10.7) | 5.2 (5.0) | 75.7 | 771 (23.4) | 1,218 (23.5) | 1,618 (23.3) | |
≥500 | <10,000 | 853 (34.3) | 6.2 (7.4) | 78.5 | 504 (15.3) | 819 (15.8) | 1,126 (16.2) |
10,000–49,999 | 367 (14.8) | 5.4 (6.1) | 75.1 | 538 (16.3) | 840 (16.2) | 1,127 (16.2) | |
≥50,000 | 225 (9.1) | 5.3 (6.5) | 77.4 | 621 (18.8) | 962 (18.5) | 1,271 (18.3) | |
Totals | 3347 (100) | 3297 (100) | 5193 (100) | 6958 (100) |
Data were weighted 100,000/2484 to estimate transmissions in a population of 100,000; The estimated per-act infectivity without a condom was 0.00094 for a person with viral load of 10,000 copies/mL and 0.00178 for a person with viral load of 50,000 copies/mL [9].
Reported = as reported in the Partners in Prevention HSV/HIV Transmission Study (77% of acts were reported protected), half = half the reported frequency of condom use in Partners in Prevention HSV/HIV Transmission Study, none = no condom use.