Table 2. Comparison of potential guidelines for ART initiation: population size requiring treatment, transmissions averted, and the ratio of % averted to % treated.

	Population eligible for treatment	Expected transmissions averted, n(%)*			Ratio % averted to % initiating
		Condom use**			Condom use**
Potential guideline	n (%)	Reported	Half	None	Reported	Half	None
By CD4 count
<500 cells/µL	41,828 (41.8)	1,569 (47.6)	2,469 (47.5)	3,297 (47.4)	1.14	1.14	1.13
By viral load
≥50,000 copies/mL	19,767 (19.8)	1,336 (40.5)	2,093 (40.3)	2,773 (39.9)	2.05	2.04	2.02
≥10,000 copies/mL	47,343 (47.3)	2,401 (72.8)	3,751 (72.2)	4,987 (71.7)	1.54	1.53	1.52
Universal treatment	100,000 (100.0)	3165 (96.0)	4985 (96.0)	6679 (96.0)	0.96	0.96	0.96

^*Expected transmissions averted shown here is based on a 96% reduction in risk with ART.

^**Reported  =  as reported in the Partners in Prevention HSV/HIV Transmission Study (77% of acts were reported protected), half  =  half the reported frequency of condom use in Partners in Prevention HSV/HIV Transmission Study, none  =  no condom use.