Table 2. Toxic effects recorded from randomized controlled trials (Grade 3–4 Adverse Events).

Studies	Intervention	Neutro-penia	Skin toxicity	Diarrhea	Thrombocytopenia	Sensory neuropathy	Fatigue
COIN [13]	FOLFOX/XELOX	13%	<1%	14%	3%	18%	18%
	FOLFOX/XELOX+Cetuximab	12%	20%	24%	3%	14%	26%
Nordic VII [14]	FLOX	47%	1%	10%	3%	22%	10%
	FLOX+Cetuximab	46%	22%	17%	4%	16%	16%
OPUS [11], [12]	FOLFOX4	34%	0.6%	7%	2%	7%	3%
	FOLFOX4+ Cetuximab	30%	11%	8%	4%	4%	4%
PRIME [15], [16]	FOLFOX4	41%	2%	9%	–	16%	3%
	FOLFOX4+Panitumumab	42%	36%	18%	–	16%	9%