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. 2012 Nov 30;7(11):e50904. doi: 10.1371/journal.pone.0050904

Figure 4. NA-induced Elk1 and SRF activation in human prostate tissue.

Figure 4

Prostate tissue from each patient was allocated to four samples, which were stimulated for indicated periods. Despite different stimulation periods, all samples were exposed for identical total periods to experimental conditions to prevent agonist-unspecific effects. Elk1 and SRF activities were asssessed by EMSA. Bands for active transcription factors (bound to DNA probes) were identified using negative controls, and are indicated by arrows. In each experiment, Elk1 or SRF in unstimulated samples ( = 0 min) was set to 100%, and values for stimulated samples were referred to the unstimulated sample. (A) NA-induced Elk1 activation (n = 9 patients). (B) NA-induced SRF activation (n = 9 patients). Shown are representative experiments, and densitometric quantification of all experiments (means±SEM).