Figure 4. The E protein and genome of virus particles can be separated in a density gradient following treatment with DN59.

Dengue virus was untreated (A), treated with 100 µM DN59 (B), or treated with 1% (v/v) triton (C), and centrifuged in a tartrate density gradient. Percent total E protein was measured by ELISA (red circles) and % total genome was measured by qRT-PCR (blue squares) in each fraction. Both peptide treatment and triton detergent treatment result in a separation of E protein and genome in the gradients.