Figure 6. Schematic representation how HP0197 contributes the CPS sysnthesis and virulence of Streptococcus suis via CcpA activity.

HP0197 could promote the level of phosphorylation of the phosphocarrier protein HPr at residue Ser-46 (HPr-Ser-46P), which could enhance the binding of CcpA to the cre of the target operons, subsequently control the expression of genes involved in carbohydrate utilization and CPS synthesis. A thin CPS could allow the pathogenic bacteria to be killed more easily by phagocytes and cleared from the host. Thus, HP0197 ultimately contributes to CPS synthesis and the virulence of S. suis via CcpA activity.