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. 2012 Nov 30;7(11):e50996. doi: 10.1371/journal.pone.0050996

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© 2012 Bisson et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Urinalysis of Podocin-Cre;Grb2^flx/flx (Cre+) and Grb2^flx/flx (Cre-) mice 6 and 18 months after birth. Average measurements and standard deviations were calculated for 3–5 mice from each group. (B–C) Representative examples of ultra-structural electron microscopy analysis of kidneys of Podocin-Cre; Grb2^flx/flx (A) and Podocin-Cre: Grb2^flx/− (B) animals compared to control (Cre-negative) littermates. Bar is 2 µm.