Table 3. Clinical utility of CSF biomarkers.

Protein	AUC*	95% CI	Optimal cut-off	Sensitivity	Specificity	False positive rate	False negative rate
Pilot (WMS) cohort
IL-12p40	0.904	0.832–0.976	2.1 pg/ml	0.743	1.000	0	0.257
CXCL13	0.735	0.602–0.868	32.68 pg/ml	0.588	0.840	0.167	0.400
IL-8	0.910	0.840–0.980	27.42 pg/ml	0.829	0.760	0.240	0.171
PCA1 (63.4%)	0.924	0.874–0.997	n/a	0.879	0.833	0.121	0.167
Confirmatory (NIB) cohort
IL-12p40	0.827	0.748–0.906	2.47 pg/ml	0.580	1.000	0	0.483
CXCL13	0.802	0.713–0.890	62.5 pg/ml	0.595	0.900	0.006	0.542
IL-8	0.806	0.717–0.895	27.98 pg/ml	0.710	0.613	0.197	0.513
PCA1 (64.3%)	0.868	0.796–0.940	n/a	0.762	0.862	0.077	0.375

^*AUC is the percentage of randomly drawn pairs for which the test is correct (i.e. it correctly classifies the two patients in the pair).