Table 2. miRNA families regulated by MAKP or PI3K/AKT signaling.

miRNA Family	miRNAs Altered	Pathway	IGF Regulation	Targets	Cellular Function
Let-7	miR-98, let-7c/g	AKT/MAPK	Down	HMGA2, Ras, Myc	Tumor Suppressor: Transformation, Proliferation
miR-16	miR-195, miR-195/miR-15b	AKT, MAPK	Down	Cyclin D1, CDK6, E2F3, VEGF, BCL2	Tumor Suppressor: Cell Cycle, Anti-angiogenic