Figure 1. α₂M-tumor peptides complexes are effective in immunotherapy.

a&b) cohorts of BALB/c mice were challenged with the CMS5 tumor as described in Methods. Mice bearing 3×3 mm diameter tumors were treated with α₂M complexed to tumor-derived peptides (a) or with gp96 complexed to peptides, peptides alone or PBS (b). Tumor growth was monitored. * is p<0.01 and ** is p<0.005 compared to α₂M-irrelevant peptide group. Purifications of α₂M were apparently homogenous as monitored by SDS-PAGE and immunoblotting with an α₂M-specific antibody (inset).