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. 2012 Nov 30;7(11):e50388. doi: 10.1371/journal.pone.0050388

Figure 7. TNBS –induced colitis is associated with increased numbers of mast cells and α-defensins.

Figure 7

(A) mRNA expression of selected mast cell specific genes in affected colon tissue (n = 5/group). Heatmap represents fold changes in TNBS colitis mice as compared to healthy control mice. (B) Quantification of toluidine blue positive cells confirmed TNBS induced up-regulation of mast cells. (C) mRNA expression of α- and β-defensin genes in affected colon tissue.