Table 1. miRNAs identified by bioinformatic approach within introns of Tbx5-modulated genes.
Microarray | Gene symbol | miRNA | Tbx5 control | Proposed biological function |
Mori/Plageman | Mest | miR-335 | positive | Trabeculation, mouse embryonic cardiac expression [54] |
Mori | Nupl 1 | miR-719 | negative | Nuclear pore complex |
Mori | Slit 2 | miR-218-1 | positive | Secreted negative regulator of axonal extension |
Mori | Hrmtl 1 | miR-678 | positive | S-adenosylmethionine-dependent methyltransferase activity |