Table 1. The percentage of gene pairs in the same pathway when p-value thresholds ranging from 1.0×10−35 to 1.0×10−5 were applied to cut off correlated lists of gene pairs resulting from eight methods.
Methods\P value | 1.0E-35 | 1.0E-25 | 1.0E-15 | 1.0E-05 | 0.05 |
Kendall | 2.51% (25,485) | 2.51% (25,499) | 1.76% (41,749) | 0.25% (1,364,076) | 0.15% (5,272,820) |
Spearman | 12.87% (404) | 5.31% (1,611) | 1.13% (87,116) | 0.24% (1,472,610) | 0.15% (5,312,831) |
Rank Theil-Sen | / | / | 0.30% (886,264) | 0.15% (5,112,691) | 0.13% (8,032,269) |
Hoeffding | / | / | / | / | 0.14% (6,927,518) |
Weighted Rank | / | / | / | 0.26% (1,279,295) | 0.15% (5,287,220) |
Theil-Sen | / | / | 0.36% (636,501) | 0.16% (4,695,948) | 0.13% (7,847,207) |
Pearson | 1.02% (17,701) | 1.09% (49,630) | 0.71% (200,325) | 0.24% (1,725,471) | 0.15% (5,486,544) |
Distance Covariance | / | / | / | / | 0.16% (4,264,095) |
(The numbers shown in parentheses are gene pairs in cut-off lists by p values).