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. Author manuscript; available in PMC: 2013 May 29.
Published in final edited form as: Nature. 2012 Oct 24;491(7426):774–778. doi: 10.1038/nature11599

Figure 4. eMLV activation in antibody-deficiency depends on husbandry conditions.

Figure 4

a, eMLV spliced env mRNA expression in the spleens of Rag1−/− mice on neutral pH (SPF) or acidified water (pH 2.5) at NIMR, on acidified water (pH 2.8) at JAX, on neutral pH at RCHCI or in germ-free (GF) facilities at UMICH (p<0.016 between Rag1−/− mice at NIMR SPF and all other groups; one-way ANOVA). b, eMLV spliced env mRNA expression in the spleens of Ighm−/−, Myd88−/− or Tlr7−/− mice on neutral pH water (SPF) at NIMR or on acidified water (pH 2.8) at JAX (p=0.005 and p=0.029 for Ighm−/− and Tlr7−/− mice, respectively; unpaired Student’s t-test). Each dot is an individual mouse and values above 103 were considered high and are indicated with red-filled symbols.