TABLE I.
Immune profiles
| Pt. 1 | Pt. 2 | |||
|---|---|---|---|---|
|
| ||||
| 16 months | 19 months | 16 months | 5 years 5 months | |
| Lymphocyte counts (cells/μl)1 | ||||
| CD3+ | 149 (1900-6200) | 205(1900-6200) | 691(1900-6200) | 777 (1400-6200) |
| CD3+CD4+ | 85 (1300-3400) | 149 (1300-3400) | 311 (1300-3400) | 443 (700-2200) |
| CD3+CD8+ | 61 (620-2000) | 42 (620-2000) | 173 (620-2000) | 293 (490-1300) |
| CD4+/CD8+ ratio | 1.4 (1.3-3.9) | 3.5 (1.3-3.9) | 1.7 (1.3-3.9) | 1.5 (0.9-3.7) |
| CD19+ | 4 (610-2600) | 1 (610-2600) | 173 (610-2600) | 15 (390-1400) |
| CD16+/CD56+ | 279 (160-1100) | 208 (160-1100) | 657 (160-1100) | 1111 (130-720) |
| Immunoglobulins (mg/dl)2 | ||||
| IgG | 193 (400-1300) | 147 (400-1300) | <152 (400-1300) | 213 (600-1500) |
| IgA | Undetectable (20-230) |
Undetectable (20-230) |
Undetectable (20-230) |
1 (50-150) |
| IgM | 54.9 (30-120) | <17.3 (30-120) | 171 (30-120) | 1048 (22-100) |
| Proliferation (c.p.m.) | ||||
| PHA | ND | 16700 (116187) | ND | 1980 (57182) |
| Anti-CD3 mAb | ND | 14310 (107265) | ND | 12558 (82957) |
The values in parentheses represent the normal range for age of lymphocyte counts, immunoglobulin concentrations, and 3H-thymidine incorporation into DNA measured as radioactive counts per minute (c.p.m.). For lymphocyte proliferation studies, a normal healthy control was studied the same day as the patient. Pt, patient; ND, not determined.
Comans-Bitter WM, de Groot R, van der Beemd R, Neijens HJ, Hop WC, Groeneveld K, et al. Immunophenotyping of blood lymphocytes in childhood. Reference values for lymphocyte subpopulations. J Pediatr 1997; 130:388-393.
Jolliff CR, Cost KM, Stivrins PC, Grossman PP, Nolte CR, Franco SM, et al. Reference intervals for serum IgG, IgA, IgM, C3, and C4 as determined by rate nephelometry. Clin Chem 1982; 28:126-128.