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The R204H mutation in IGF1R is predicted to destroy three hydrogen bonds within a nonsolvent accessible region of the cysteine-rich domain. a The structure determined by Garrett et al. (1998) with arginine at 204. The arginine side chain is at the center of the image. b The structure with histidine at residue 204 where putative hydrogen bonds to S153 (carbonyl), E200 (side chain), and T195 (side chain) have been lost
