Figure 6.

Representative results of tumor-specific cell killing by AAV2 vectors carrying DT-A under the control of the survivin promoter. The cells were seeded in 24-well plate and transduced with (a,c,e,g) AAV2-CMV-GFP or (b,d,f,h) AAV2-hSURV-inDTA(hGH). Photographs were taken 3 days post-transduction. (a,b), WI38; (c,d), HepG2; (e,f), Hep3B, and (g,h), BE(2)-M17 cells. AAV, adeno-associated virus; CMV, cytomegalovirus; DT-A, diphtheria toxin fragment A; GFP, green fluorescent protein; hGH, human growth hormone.