Table 1.
Clinical characteristics of 11 individuals carrying germline HOXB13 G84E mutation
| No. | Origin | Subjects | Age at diagnosis, y | Estrogen receptor | Progesterone receptor | HER2 | Grade | Family historyb |
|---|---|---|---|---|---|---|---|---|
| 1 | Canada | Case | 78 | + | + | ? | Ca ductal G3 | None |
| 2 | Canada | Case | 74 | + | + | – | Ca ductal G2 | Father (PrCa), maternal aunt (BrCa) |
| 3 | Poland | Case | 50a | + | ++ | – | Ca ductal Gx | None |
| 4 | Poland | Case | 50 | – | – | – | Ca ductal G3 | None |
| 5 | Poland | Case | 47 | + | – | ? | Ca ductal G1, G2 | Mother (BrCa), paternal aunt (BrCa) |
| 6 | Poland | Case | 47 | – | – | + | Ca ductal G1, G2 | Father (PrCa), paternal grandfather (PrCa) |
| 7 | Poland | Case | 41 | – | – | + | Ca medullar | None |
| 8 | Canada | Control | 57 | NA | NA | NA | NA | None |
| 9 | Poland | Control | 50 | NA | NA | NA | NA | None |
| 10 | Poland | Control | 70 | NA | NA | NA | NA | None |
| 11 | Poland | Control | 40 | NA | NA | NA | NA | None |
aPoland cases were selected for their age and they were all under 50 years of age
bFamily history of breast cancer (BrCa) and prostate cancer (PrCa) among the first-and second-degree relatives of the probands
(+) or (++) positive; (–) negative; ? unknown; NA not available; HER2 Human Epidermal Growth Factor Receptor 2