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. 2012 May 1;31(1):40. doi: 10.1186/1756-9966-31-40

Figure 1.

Figure 1

VEGF expression after in vitro treatment with bevacizumab. Both 10 and 100 μg/mL bevacizumab decreased the level of VEGF in C4-2B only, compared with control IgG. There were significant differences in the VEGF levels between the 10 or 100ug/ml bevacizumab and control IgG (P < 0.01). Human bone metastatic prostate cancer cell co-cultured with human microvessel cell expressed 6 times more VEGF than did tumor cultured cell only, and this level significantly decreased after treatment with 10 or 100 μg/mL bevacizumab.