Table 1.

Analgesic effects of delta opioid agonists

Agonist	Pain model#	Species	Pain Modality	Reference
DPDPE*/ DSLET	Formalin	Rat		(Obara et al., 2009)
	Capsaicin	Rat		(Saloman et al., 2011)
	Inflammatory	Rat	M*	(Stein et al., 1989)
		Mouse	H*	(Hervera et al., 2009)
		Rat	M	(Zhou et al., 1998)
	Neuropathic	Mouse	H, M, C*	(Hervera et al., 2010)
		Rat	H, M	(Obara et al., 2009)
		Rat	C	(Mika et al., 2001)
	Cancer	Mouse	H	(Baamonde et al., 2005)
Deltorphin	Formalin	Mouse		(Morinville et al., 2003)
		Rat		(Bilsky et al., 1996)
		Rat		(Cahill et al., 2001)
		Rat		(Pradhan et al., 2006)
	Inflammatory	Rat	H	(Fraser et al., 2000)
		Rat	H	(Hurley & Hammond, 2000)
		Rat	H	(Cahill et al., 2003)
		Rat	H	(Gendron et al., 2007a)
		Rat	M	(Otis et al., 2011)
		Rat	H	(Beaudry et al., 2009)
		Mouse	H	(Gendron et al., 2007b)
		Mouse	H	(Dubois & Gendron)
	Neuropathic	Rat	C	(Mika et al., 2001)
		Rat	M, C	(Holdridge & Cahill, 2007)
		Rat	M	(Kabli & Cahill, 2007)
	Cancer	Rat	M	(Otis et al., 2011)
SNC80	Formalin	Mouse		(Barn et al., 2001)
		Rat		(Obara et al., 2009)
	GDNF hyperalgesia	Rat	M	(Joseph & Levine)
	NGF hyperalgesia	Rat	M	(Joseph & Levine)
	PGE2 hyperalgesia	Monkey	H	(Brandt et al., 2001)
		Rat	M	(Pacheco & Duarte, 2005)
	Dynorphin A allodynia	Rat	M	(Kawaraguchi et al., 2004)
	Inflammatory	Monkey	H	(Brandt et al., 2001)
		Rat	H	(Fraser et al., 2000)
		Rat	M	(Cao et al., 2001)
		Rat	H	(Gallantine & Meert, 2005)
		Mouse	H	(Gendron et al., 2007b)
		Mouse	H, M	(Gaveriaux-Ruff et al., 2008)
		Mouse	H, M	(Pradhan et al., 2009;
				Pradhan et al., 2010)
	Neuropathic	Mouse	M	(Scherrer et al., 2009)
		Monkey	H	(Brandt et al., 2001)
		Mouse	M	(Scherrer et al., 2009)
		Mouse	H, M	(Gaveriaux-Ruff et al., 2011)
		Rat	H, M	(Obara et al., 2009)
Tan-67	Formalin	Mouse		(Barn et al., 2001)
	Diabetes	Mouse	H	(Kamei et al., 1997)
SB-235863	Inflammatory	Rat	H	(Petrillo et al., 2003)
		Rat	H	(Beaudry et al., 2009)
	Neuropathic	Rat	H	(Petrillo et al., 2003)
DValAla-Enk	Cancer	Mouse	M	(Brainin-Mattos et al., 2006)
AR-M100390	Inflammatory	Mouse	H, M	(Pradhan et al., 2009)
		Mouse	H, M	(Pradhan et al., 2010)
NIH 11082	Inflammatory	Rat	M	(Aceto et al., 2007)
ADL5859	Inflammatory	Rat	M	(Le Bourdonnec et al., 2008)
ADL5747	Inflammatory	Rat	M	(Le Bourdonnec et al., 2009)
JNJ-20788560	Inflammatory	Rat	H	(Codd et al., 2010)
Compound 8e	Inflammatory	Rat	n.i.	(Jones et al., 2009)
KNT-127	Formalin	Mouse		(Saitoh et al., 2011)

^#Visceral pain was induced by intraperitoneal acetic acid injection; inflammatory pain by injection of Complete Freund’s Adjuvant (CFA) , zymosan, yeast, or carrageenan ; neuropathic pain was induced by sciatic nerve or spinal nerve ligation; cancer pain by injection of NCTC 2472 osteosarcoma cells,

^*Abbreviations: C, cold: DPDPE, (D-Pen2, D-Pen5)-enkephalin; DSLET, (D-Ser2,Leu5)-enkephalin; GDNF Glial cell line-derived neurotrophic factor; H, heat; M mechanical; NGF, nerve growth factor; PGE2, prostaglandin-E2