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The (−)-notoamide A (not), (+)-notoamide A (not′), paraherquamide (phq), and malbrancheamide (mal) biosynthetic gene clusters identified from genome sequencing and bioinformatic mining of Aspergillus sp. MF297-2, Aspergillus versicolor NRRL35600, P. fellutanum ATCC20841, and M. aurantiaca RRC1813, respectively. Homology of open reading frames across gene clusters is shown by same colored arrows. The not and not′ genes in the red box are unlikely involved in notoamide biosynthesis.
